胡韬
党支部宣传委员
脊柱融合的组织工程复合物和干细胞治疗，骨质疏松微环境中炎症因子表达，骨科内固定材料的特种生物活性涂层
AOSpine会员
1.主持课题：国家自然科学基金青年基金1项： 缓释BMP2通过SMAD-NFkB-紧密连接蛋白通路减轻脊柱融合手术周围炎症反应的分子机制研究；中央高校基本科研业务费（同济大学青年优秀人才培养行动计划）骨髓间充质干细胞结合缓释骨形态发生蛋白改善脊柱融合微环境的分子机制研究 ；中科院上海硅酸盐研究所特种无机涂层重点实验室开放课题，适用于骨质疏松患者的脊柱植入物涂层研究；上海市东方医院旭日青年人才培养计划。 2.所获荣誉：2017 International Society for the Study of the Lumbar Spine (ISSLS) Outstanding Poster Award，2018 UNMC-Tongji Observership；2019 International Travelling Fellowship of AOSpine。 3.发表文章：SCI 30余篇，包括《Spine》《The Spine Journal》《Tissue Engineering Part A》《Journal of Tissue Engineering and Regenerative Medicine》《Chemical Engineering Journal》《Advanced Healthcare Materials》《Materials Science and Engineering C》《ACS Biomaterials Science》《Advanced Materials Interfaces》等 1.T. Hu, M. Naidu, Z. Yang, W. M. Lam, R. A. Kumarsing, X. Ren, F. Ng, M. Wang, L. Liu, K. C. Tan, K. T. Kwok, S. B. Goodman, J. C. Goh, and H. K. Wong, "Bone Regeneration by Controlled Release of Bone Morphogenetic Protein-2: A Rabbit Spinal Fusion Chamber Molecular Study," Tissue engineering. Part A (2019). 25：1356-1368 2.Hu T, Abbah SA, Ming W, Toh SY, Lam WM, , G Bhakta, S Cool, K Bhakoo, J Li, Goh J, Wong HK. Novel protamine based polyelectrolyte carrier enhance low dose rhBMP-2 in posterolateral spinal fusion. Spine. 2015, 1;40(9):613-21. 3.Hu T, Abbah SA, Toh SY, Wang M, Lam RW, G Bhakta, S Cool, K Bhakoo, J Li, Goh JC, Wong HK. Bone-marrow derived mesenchymal stem cells assembled with low dose BMP-2 in a three dimensional hybrid construct enhances posterolateral spinal fusion in syngeneic rats. Spine J. 2015 1;15(12):2552-63. 4.Hu T, Luo Z, Li K, Wang S, Wu D. Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability. Biosci Rep. 2020 Oct 30;40(10):BSR20201098. 5. Hu T, Liu L, Lam RWM, et al. Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. J Tissue Eng Regen Med, 2022, 16(1): 63-75. 6.Guo Y, Li C, Shen B, Zhu Z, Chen X, Hu T, Wu D. Is There Any Relationship between Plasma IL-6 and TNF-α Levels and Lumbar Disc Degeneration? A Retrospective Single-Center Study. Dis Markers. 2022 Jan 19;2022:6842130. doi: 10.1155/2022/6842130. PMID: 35096205; PMCID: PMC8791708. 7.Shao DD, Li k, Hu T,Wang SJ,Xu HW,Zhang SB,Liu SW,Xie YT,Zheng XB. Titania nanotube array supported nanoceria with redox cycling stability ameliorates oxidative stress-inhibited osteogenesis. Chemical Engineering Journal. Volume 415,1 July 2021,128913 . 8.L. Liu, W. M. R. Lam, M. Naidu, Z. Yang, M. Wang, X. Ren, T. Hu, R. Kumarsing, K. Ting, J. C. Goh, and H. K. Wong, "Synergistic Effect of NELL-1 and an Ultra-Low Dose of BMP-2 on Spinal Fusion," Tissue engineering. Part A (2019). 2019 Dec;25(23-24):1677-1689 9.L. Liu, W. M. R. Lam, Z. Yang, M. Wang, X. Ren, T. Hu, Jun Li, J. C. Goh, and H. K. Wong, "Improving the handling properties and long-term stability of polyelectrolyte complex by freeze-drying technique for low-dose bone morphogenetic protein 2 delivery. J Biomed Mater Res. 2020 Aug;108(6):2450-2460 10.S. F. Husain, R. W. M. Lam, T. Hu, M. W. F. Ng, Z. Q. G. Liau, K. Nagata, S. Khanna, Y. Lam, K. Bhakoo, R. C. M. Ho, and H. K. Wong, "Locating the Site of Neuropathic Pain In Vivo Using MMP-12-Targeted Magnetic Nanoparticles," Pain research & management 2019, 9394715 (2019). 11.G. Bhakta, A. K. Ekaputra, B. Rai, S. A. Abbah, T. C. Tan, B. Q. Le, A. Chatterjea, T. Hu, T. Lin, M. T. Arafat, A. J. van Wijnen, J. Goh, V. Nurcombe, K. Bhakoo, W. Birch, L. Xu, I. Gibson, H. K. Wong, and S. M. Cool, "Fabrication of polycaprolactone-silanated beta-tricalcium phosphate-heparan sulfate scaffolds for spinal fusion applications," The spine journal : 18 (5), 818-830 (2018). 12.Z. Q. G. Liau, R. W. M. Lam, T. Hu, and H. K. Wong, "Dose-dependent Nerve Inflammatory Response to rhBMP-2 in a Rodent Spinal Nerve Model," Spine 42 (16), E933-e938 (2017). 13.Wang M, Abbah SA, Hu T, Lam RW, Toh SY, T Liu, Cool S, Bhakoo S, Li J, Goh JC, Wong HK. Polyelectrolyte complex carrier enhances therapeutic efficiency and safety profile of bone morphogenetic protein-2 in porcine lumbar interbody fusion model. Spine (Phila Pa 1976). 2015 1;40(13):964-73. 14.Wang M, Lam RW, Abbah SA, Hu T, Toh SY, Cool S, Bhakoo K, Li J, Goh JC, Wong HK. Heparin-based polyelectrolyte complex enhances the therapeutic efficacy of bone morphogenetic protein-2 for posterolateral fusion in a large animal model. Spine. 2016 1;41(15):1199-207. 15.Li K, Lu X, Razanau I, Wu X, Hu T, Liu S, Xie Y, Huang L, Zheng X. The enhanced angiogenic response to ionic dissolution products from boron incorporated calcium silicate coatings. Materials Science & Engineering C. 2019,513-520. 16.Shao D, Li K, You M, Liu S, Hu T, Huang L, Xie Y, Zheng X. Macrophage polarization by plasma sprayed ceria coatings on titanium-based implants: cerium valence state matter. Applied Surface Science. 504. 17.L. Lv, Y. Xie, K. Li, T. Hu, X. Lu, Y. Cao, and X. Zheng, "Unveiling the Mechanism of Surface Hydrophilicity-Modulated Macrophage Polarization," Advanced healthcare materials 7 (19), e1800675 (2018). 18.Xu HW, Yi YY, Zhang SB, Hu T, Wang SJ, Zhao WD, Wu DS. Does vitamin D status influence lumbar disc degeneration and low back pain in postmenopausal women? A retrospective single-center study. Menopause. 2020 Feb 10. doi: 10.1097/GME.0000000000001499. 19.Wang SJ, Cao DL, Xu HW, Zhao WD, Hu T, Wu DS. Development of Primary Diffuse Large B-cell Lymphoma around an Internal Fixation Implant after Lumbar Fusion Surgery. World Neurosurg. 2020 Feb 5. pii: S1878-8750(20)30245-X. 20.Xu HW, Shen B, Hu T, Zhao WD, Wu DS, Wang SJ. Preoperative vitamin D status and its effects on short-term clinical outcomes in lumbar spine surgery. J Orthop Sci. 2019 Nov 20. pii: S0949-2658(19)30332-X. 21.Shen B, Zhou N, Hu T, Zhao W, Wu D, Wang SJ. LncRNA MEG3 negatively modified osteosarcoma development through regulation of miR-361-5p and FoxM1. J Cell Physiol. 2019 Aug;234(8):13464-13480. 22.Liu S, Li K, Hu T, Shao D, Huang S, Xie Y, Zheng X. Zn-doped MnO2 nano coating with enhanced catalase-mimetic activity and cytocompatibility protects pre-osteoblasts against H2O2-induced oxidative stress. Colloids and Surfaces B：Biointerfaces.2021,201,111666. 23. Wang M, Abbah SA, Hu T, et al. Minimizing the severity of rhBMP-2-induced inflammation and heterotopic ossification with a polyelectrolyte carrier incorporating heparin on microbead templates. Spine (Phila Pa 1976), 2013, 38(17): 1452-1458. 24. Abbah SA, Lam WM, Hu T, et al. Sequestration of rhBMP-2 into self-assembled polyelectrolyte complexes promotes anatomic localization of new bone in a porcine model of spinal reconstructive surgery. Tissue Eng Part A, 2014, 20(11-12): 1679-1688 25. Liu SW, Li K, Hu T, et al. Controlling Preosteoblast Behavior through Manganese Vacancy-Rich Birnessite with Enhanced Divalent Cation Modulation of Fibronectin-Integrin Interactions. Advanced Materials Interfaces, 2020, 7(12). 26. Li K, Liu SW, Hu T, et al. Optimized Nanointerface Engineering of Micro/Nanostructured Titanium Implants to Enhance Cell-Nanotopography Interactions and Osseointegration. Acs Biomaterials Science & Engineering, 2020, 6(2): 969-983. 27.Xu HW, Zhang SB, Yi YY, Chen H, Hu T, Wang SJ, Wu DS. Relationship between Vitamin D and Nonspecific Low Back Pain May Be Mediated by Inflammatory Markers. Pain Physician. 2021 Nov;24(7):E1015-E1023. 28.Yi YY, Xu HW, Zhang SB, Hu T, Wang SJ, Wu DS. Does the C3/4 disc play a role in cervical spondylosis with dizziness? A retrospective study. Int Orthop. 2020 Jun;44(6):1159-1168. doi: 10.1007/s00264-020-04531-y. Epub 2020 Mar 19 29.Zhang SB, Xu HW, Yi YY, Hu T, Wang SJ, Wu DS. Evaluation of the Use of CT Attenuation for the Prediction of Subsequent Vertebral Fracture in Patients with Osteoporosis. Pain Physician. 2021 Jul;24(4):E493-E500. 30.Chen H, Yi YY, Zhang SB, Xu HW, Fang XY, Tao-Hu, Wu DS, Wang SJ. Sarcopenic obesity defined by visceral adiposity was associated with osteoporotic vertebral fracture. Arch Osteoporos. 2022 Mar 6;17(1):41.
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